Sepsis and Systemic Inflammatory Syndromes, An Issue of Critical Care Clinics

In this issue of Critical Care Clinics, guest editors Drs. Manu Shankar-Hari and Lieuwe D. J. Bos bring their considerable expertise to the topic of Sepsis and Systemic Inflammatory Syndromes. Sepsis and systemic inflammatory syndromes represent life-threatening medical emergencies and remain leading causes of morbidity and mortality worldwide. Advances in early detection, biomarker development, and targeted immunomodulatory therapies continue to reshape clinical practice, making this issue especially timely for clinicians in emergency medicine, critical care, and multiple medical specialties.<ul><li>Contains 13 relevant, practice-oriented topics including novel trial designs in critically ill patients; principles of drug discovery with extreme phenotypes of critical illness; non-immune host response to sepsis; AMR in sepsis; sepsis and the immunocompromised host; acute inflammation; and more. </li><li>Provides in-depth clinical reviews on sepsis and systemic inflammatory syndromes, offering actionable insights for clinical practice. </li><li>Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. </li></ul>