Genomic Surveillance And Pandemic Preparedness

Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how and why genomic surveillance may be applied. Drawing heavily from learnings during the Covid-19 pandemic, this book covers viral genome sequencing analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation types and speeds, RNA modulation of infection, pathogen diversity, and the role of co-infections and co-morbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent Covid-19 analysis, are discussed. Finally, authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines.