NMR Analyses of Membrane Proteins and Supramolecular Complexes

NMR has the unique ability to analyse the structure and dynamics of proteins in physiological conditions and directly connect these characteristics to their function. However, in routine studies, the size limitations of the biomolecular systems still present challenges. The field continues to develop methodology and instrumentation, pushing their frontiers and redefining limitations, and research into the understanding of how membrane proteins and supramolecular protein complexes can dynamically change their structures to exert their biological and pharmacological functions are producing results. This book presents detailed descriptions of the methodologies for structurally analysing large molecular weight systems along with the landmark achievements in the NMR analysis of membrane proteins and supramolecular protein complexes. Other structural technologies that complement NMR-derived information are discussed. Describing the current state of the art in this field, this book attempts to illuminate the challenges that still need to be addressed to realize the full potential of NMR. This book covers hot research fields beneficial not only to NMR specialists but also to biologists, biochemists, molecular biologists and medicinal chemists. Providing comprehensive research examples, it will be of benefit to postdocs and PhD candidates, enabling them to improve the design of their experiments. Since membrane proteins and supramolecular complexes contain many drug targets, researchers in the pharmaceutical industry will also find information of interest here.