Preclinical Drug Development

<P><STRONG>Preclinical Drug Development, Second Edition</STRONG> discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. </P><P>Highlights of the Second Edition include: </P><UL><P><LI>Pharmacokinetics</LI><LI>Modeling and simulation</LI><LI>Formulation and routes of administration</LI><LI>Toxicity evaluations</LI><LI>The assessment of drug absorption and metabolism</LI><LI>Interspecies scaling </LI><LI>Lead molecule selection and optimization via profiling</LI><LI>Screening using <I>in silico</I> and <I>in vitro</I> toxicity evaluations </LI><P></P></UL><P></P><P>The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide