Iron–Sulfur Clusters – Biogenesis and Biochemistry

An authoritative and up-to-date collection of resources covering the ubiquitous iron-sulfur cluster-containing proteins In Iron-Sulfur Clusters: Biogenesis and Biochemistry, a team of distinguished researchers delivers an incisive and practical discussion of the assembly and role of metalloproteins containing an iron atom in a mononuclear or binuclear metal-active site, or where the assembly and final activity of the enzyme depends on an Fe-S cluster containing protein. The book examines the crosstalk in the assembly of metal-active sites and the roles played by various metal ions in polynuclear metalloclusters. It also describes metal homeostasis and trafficking in a cellular context and explains why the availability of metal ions is tightly regulated. Of particular interest to chemists working with iron-sulfur (Fe-S) clusters in biology, biochemistry, pharmaceuticals, and drug synthesis, the book also contains: A thorough introduction to the biosynthesis of hydrogenase cofactors and hydrogenase reaction mechanismsComprehensive explorations of the reaction mechanisms of molybdoenzymes, including sulfite oxidase, aldehyde oxidase, and formate dehydrogenasePractical discussions of the biosynthesis of Fe-S clusters in prokaryotes and eukaryotesComplete examinations of the insertion of Fe-S clusters and the biosynthesis of Moco and FeMocoAn overview of the chemical, crystallographic, spectroscopic and theoretical methods commonly used to characterize Fe-S clusters. Perfect for biochemists and protein, pharmaceutical, bioinorganic, and organic chemists, Iron-Sulfur Clusters will also be useful for food and environmental chemists, as well as professionals working in the pharmaceutical industry.